CD3δ Establishes a Functional Link between the T Cell Receptor and CD8
نویسندگان
چکیده
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the investigation of the relationship between type a and type b personalities and quality of translation
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T cell receptor binding affinity governs the functional profile of cancer-specific CD8+ T cells
Antigen-specific T cell receptor (TCR) gene transfer via patient-derived T cells is an attractive approach to cancer therapy, with the potential to circumvent immune regulatory networks. However, high-affinity tumour-specific TCR clonotypes are typically deleted from the available repertoire during thymic selection because the vast majority of targeted epitopes are derived from autologous prote...
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which means that the parameter ν is fixed once γkin and δ have each been assigned a value. The objective of the paper was to exhibit the range of qualitative behaviors that is possible when pMHCI/CD8 kinetics interacts with TCR/pMHCI kinetics and to show how varying levels of the co-receptor at the T-cell surface may be able to modulate the functional sensitivity of the T-cell to various ligand...
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Adoptive transfer of cross-reactive HSP60-specific CD8(+) T cells into immunodeficient mice causes autoimmune intestinal pathology restricted to the small intestine. We wondered whether local immunopathology induced by CD8(+) T cells can be explained by tissue-specific differences in proteasome-mediated processing of major histocompatibility complex class I T cell epitopes. Our experiments demo...
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The action of TdT on mouse TCR genes accounts for approximately 90% of T cell repertoire diversity. We report that in TdT-/- mice, total T(CD8+) responses to influenza and vaccinia viruses are reduced by approximately 30% relative to wild-type mice. We find that T(CD8+) responses to three subdominant influenza virus determinants are reduced to background values in TdT-/- mice while responses to...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2003
ISSN: 0021-9258
DOI: 10.1074/jbc.m208119200